Symmetrical drug-related intertriginous and flexural exanthema induced by clarithromycin*
نویسندگان
چکیده
of lichen planus follicularis tumidus and Hashimoto’s thyroiditis. An Bras Dermatol. 2017;92(4):585-7. Mailing address: Hatice Kaya Ozden Kocaeli Derince Training and Research Hospital Dermatology Department 41900 Kocaeli / Turkey E-mail: [email protected] We observed a slightly itchy, tumid, violaceous plaque in our patient only in the left retroauricular region and classic lichen planus lesions or systemic symptoms of hypothyroidism were not present. Histopathological examination, besides the pathognomonic findings of lichen planus, revealed band–like lichenoid infiltrate surrounding the follicles and cysts. Therefore, identifying this entity was critical to reach the LPFT diagnosis and to detect the underlying autoimmune disease. LPFT tends to be chronic, relapsing, and hard to treat. Consequently, all current treatments available are generally disappointing. In our patient, as LPFT is hard to cure and was localized in a small area, clobetasol propionate cream 0.05% therapy is recommended despite the retroauricular localization of the lesion. Additionally, we warned our patient to come to our endocrinology department for control as soon as she noticed symptoms of hypothyroidism or every 6-12 months. We decided to report on this case not only because LPFT is a very rare clinical variant, but also because it was observed for the first time with autoimmune thyroiditis in the present case. q
منابع مشابه
Symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir.
Drug-related eruptions that appear only on intertriginous or flexural folds and in gluteal areas have recently been termed symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). We report a case of a 56-year-old woman with acute erythematous rash in the intertriginous areas after treatment with the L-valine ester of acyclovir, valacyclovir. Oral-challenge tests resulted in ery...
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متن کاملSymmetrical drug-related intertriginous and flexural exanthema.
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Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous drug reaction characterized by erythema over the buttocks, thighs, groin, and flexural regions most commonly associated with the use of beta-lactam antibiotics. Although the exact pathophysiology of this disease remains unknown, it is theorized to be the result of a delayed hypersensitivity response presentin...
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عنوان ژورنال:
دوره 92 شماره
صفحات -
تاریخ انتشار 2017